Mohnish Sekar; Arun Inamadar; Ajit Janagond
Abstract
Background: Atopic dermatitis (AD) is a prevalent, chronic, inflammatory skin disorder that primarily affects children, with just a few cases persisting into adulthood. Many theories exist to ascertain the relationship between atopic dermatitis and systemic inflammation. Neutrophil lymphocyte ratio (NLR), ...
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Background: Atopic dermatitis (AD) is a prevalent, chronic, inflammatory skin disorder that primarily affects children, with just a few cases persisting into adulthood. Many theories exist to ascertain the relationship between atopic dermatitis and systemic inflammation. Neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and Mean platelet volume (MPV) are biomarkers of systemic inflammation, which in turn are related to atopic dermatitis. The present study aimed to assess the association between atopic dermatitis and NLR, PLR, and MPV values by calculating NLR, PLR, and MPV ratio and correlating their levels with the disease duration and severity of AD in pediatric atopic dermatitis.Methods: This cross-sectional study included 165 pediatric atopic dermatitis patients who met the clinical confirmation criteria of the U.K. working party. The patients with co-existing conditions such as molluscum contagiosum, impetigo, hand-foot and-mouth disease, and eczema herpeticum were excluded. The mean ± SD values of NLR, PLR, and MPV were compared after the severity groups were classified using SCOR Atopic Dermatitis (SCORAD). The association of SCORAD and disease duration with NLR, PLR, and MPV levels was evaluated.Results: Significant differences were noted between severity groups based on NLR, PLR, and MPV values. PLR and NLR had a positive correlation with the SCORAD score, whereas MPV was negatively correlated. In addition, NLR had a positive correlation with disease duration. PLR exhibited a higher diagnostic accuracy in predicting high SCORAD with a 100% sensitivity and specificity cut-off value of > 172.Conclusion: NLR, PLR, and MPV were cost-effective, feasible, andwidely available tests to detect systemic inflammation in AD with high sensitivity and specificity.
Warood Albadri; Shiva Shankar Marri; M Kavya; Bhargavi M Uttmani; Arun Inamadar
Abstract
Diet plays a critical role in the maintenance of various physiological functions in cutaneous structures. Inadequacy of a well-balanced diet gives rise to a constellation of skin manifestations, which are frequently mild and non-specific; hence, overlooked or misdiagnosed. However, it can lead to serious ...
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Diet plays a critical role in the maintenance of various physiological functions in cutaneous structures. Inadequacy of a well-balanced diet gives rise to a constellation of skin manifestations, which are frequently mild and non-specific; hence, overlooked or misdiagnosed. However, it can lead to serious complications. This group of dermatoses affects both developing and developed countries. Children, in particular, are more prone due to increased demand for nutrients for growth and development, as well as negligence or inability to provide by the caretaker. The dermatologist might be the first physician to come across such patients since cutaneous features are more apparent. Hence, a strong clinical suspicion for multiple micro- or macronutrient deficiencies should be maintained since many conditions may have overlapping presentations such as xerosis, periorificial and intertriginous dermatitis, photo-distributed dermatitis, seborrheic dermatitis-like lesions, follicular hyperkeratosis, intracutaneous hemorrhages, impaired wound healing, pigmentary changes, and others including mucosal manifestations and hair and nail changes. This review article discussed an approach to nutritional dermatoses in the pediatric age group to aid in accurate diagnosis and timely treatment.
